Transfection by cationic gemini lipids and surfactants

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Gene Transfection in High Serum Levels: Case Studies with New Cholesterol Based Cationic Gemini Lipids

BACKGROUND Six new cationic gemini lipids based on cholesterol possessing different positional combinations of hydroxyethyl (-CH2CH2OH) and oligo-oxyethylene -(CH2CH2O)n- moieties were synthesized. For comparison the corresponding monomeric lipid was also prepared. Each new cationic lipid was found to form stable, clear suspensions in aqueous media. METHODOLOGY/PRINCIPAL FINDINGS To understan...

متن کامل

Gemini surfactants: new synthetic vectors for gene transfection.

The superior surfactant properties of cationic gemini surfactants are applied to the complex problem of introducing genes into cells. Of almost 250 new compounds tested, of some 20 different structural types, a majority showed very good transfection activity in vitro. The surfactant is shown to bind and compact DNA efficiently, and structural studies and calculations provide a working picture o...

متن کامل

Structure-activity correlation in transfection promoted by pyridinium cationic lipids.

The efficiency of the transfection of a plasmid DNA encoding a galactosidase promoted by a series of pyridinium lipids in mixtures with other cationic lipids and neutral lipids was assessed in CHO-K1 cells. We identify key molecular parameters of the lipids in the mixture - clog P, lipid length, partial molar volume - to predict the morphology of the lipid-DNA lipoplex and then correlate these ...

متن کامل

Corrosion Inhibition Effect of Ester Containing Cationic Gemini Surfactants on Low Carbon Steel

α, ω-alkane-bis(N-myristoyloxyethyl-N, N-dimethyl)-diammonium bromide were synthesized<span style="font-size: 10.0pt; line-height...

متن کامل

Wormlike micelles formed by mixed cationic and anionic gemini surfactants in aqueous solution.

The formation and the properties of wormlike micelles in aqueous solutions of mixed cationic and anionic gemini surfactants, 2-hydroxyl-propanediyl-α,ω-bis(dimethyldodecylammonium bromide) (12-3(OH)-12) and O,O'-bis(sodium 2-dodecylcarboxylate)-p-benzenediol (C(12)ϕC(12)), have been studied by steady-state and dynamic rheological measurements at 25°C. With the addition of a small amount of C(12...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: MedChemComm

سال: 2018

ISSN: 2040-2503,2040-2511

DOI: 10.1039/c8md00249e